1,2-Dichloroethane → HCID 131725245, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 10 (Step b) using N-((1R)-1-[(4-chlorophenyl)methyl]-2 oxo-2-{4-[2-(2-oxo(4-imidazolinyl))phenyl]-piperidyl}ethyl)(tert butoxy)carboxamide (Step b) (0.283 g, 0.54 mmol) and satd anhydrous HCl in EtOAc, followed by Boc-L-TicOH (Advanced ChemTech) (0.18 g, 0.65 mmol), EDC (Advanced ChemTech) (0.155 g, 0.81 mmol), HOBT (Novabiochem) (0.073 g, 0.54 mmol) and TEA (Aldrich) (0.075 mL, 0.54 mmol) in CH2Cl2 (10 mL). Purification by silica gel chromatography (100% EtOAc then 1:9 MeOH:EtOAc) provided the title compound as a white foam (0.3 g). MS (ESI, pos. ion) m/z: 684 (M+1). Calc'd for C38H42ClN5O5: 683.29.

Provenance & Evidence