Hydrochloric Acid → HCID 60054560, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 10 (Step c) from tert-butyl (3S)-3-[N-((1R)-1-[(4-chlorophenyl)methyl]-2-oxo-2-(4-[2-(2-oxo(4-imidazolinyl))phenyl]piperidyl)ethyl) carbamoyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate (Step c) (0.3 g, 0.44 mmol) and satd anhydrous HCl in EtOAc (20 mL). Recrystallization from 1:20 MeOH:Et2O provided the title compound (HCl salt) as a white solid (0.15 g). MP 191° C. (decomposed). MS (ESI, pos. ion) m/z: 584 (M+1). Calc'd for C33H34ClN5O3: 597.25. Anal. Calcd for C33H34ClN5O3HCl.2.25H2O: C, 59.95; H, 6.02: N, 10.59; Cl, 10.13. Found: C, 59.93; H, 5.83; N, 10.45; Cl, 10.57.

Provenance & Evidence