1,2-Dichloroethane → HCID 23587432, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 1 (Step f) from (fluoren-9-ylmethoxy)-N-(2-(4-piperidyl)phenyl)-carboxamide hydrochloride (Step b) (6.51 g, 15 mmol), DIEA (2.7 mL, 15 mmol), Boc-p-Cl-D-PheOH (PepTech Corporation) (6.8 g, 22.5 mmol), HOAT (Aldrich) (3.1 g, 22.5 mmol) and EDC (Aldrich) (4.32 g, 22.5 mmol) in DMF (25 mL). Purification by silica gel chromatography (3:1 hexane:EtOAc) provided the title compound as a white foam (6.87 g). MS (ESI, pos. ion) m/z: 680 (M+1); MS (ESI, neg. ion) m/z: 678 (M−1). Calc'd for C40H42ClN3O5: 679.28.

Provenance & Evidence