Water → HCID 12088101, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium aluminum hydride (3.32 g, 70.0 mmol) in tetrahydrofuran (200 ml) was added dropwise a solution of 1-[3-(methyloxy)propyl]-4-piperidinecarboxamide (step 1, 7.00 g, 35.0 mmol) in tetrahydrofuran (50 ml) at 0° C. over 15 minutes. The mixture was stirred at 0° C. for 30 min and at 40° C. for 1.5 h. After cooling to 0° C., water (3.3 ml), 15% aqueous sodium hydroxide (3.3 ml) and water (10 ml) were carefully added dropwise. The resulting mixture was filtered through a pad of Celite and the filtrate was concentrated in vacuo to give 6.31 g (97%) of the title compound as a pale yellow oil.

Provenance & Evidence