Tert-butyl 4-[3-(6-amino-2-methoxy-3-pyridinyl)-3-oxopropyl]-1-piperidinecarboxylate → 1-(6-Amino-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone

HRID 489797Notes

Reaction equation

HRID 489797 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:26])[CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[CH:4][CH:3]=1.NC1N=C(OC)C(C(=O)CCC2CCN(C(OC(C)(C)C)=O)CC2)=CC=1Cl>>[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:26])[CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 22262602Tert-butyl 4-[3-(6-amino-2-methoxy-3-pyridinyl)-3-oxopropyl]-1-piperidinecarboxylateHCID 22262604Tert-butyl 4-{3-[6-amino-5-chloro-2-(methyloxy)-3-pyridinyl]-3-oxopropyl}-1-piperidinecarboxylate

Product 1

HCID 222626571-(6-Amino-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone

Procedure

The title compound was prepared according to the procedure of step 5 in the example 9 using tert-butyl 4-[3-(6-amino-2-methoxy-3-pyridinyl)-3-oxopropyl]-1-piperidinecarboxylate (step 3 in example 9), instead of tert-butyl 4-{3-[6-amino-5-chloro-2-(methyloxy)-3-pyridinyl]-3-oxopropyl}-1-piperidinecarboxylate.

Sources & evidence

ORD record
ord-3c83991a502c4ff6a44e2b0959cee376
Source dataset
uspto-grants-2005_12
Patent number
US06979690B2

Reaction notes

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