HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodobenzene → 4-Amino-2'-methylbiphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Benzenamine, 4-methyl-N-(4-methylphenyl)- | HCID 69293 | — |
| Reactant | sodium 2-methylpropan-2-olate | HCID 178418730 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 4-Amino-2'-methylbiphenyl | HCID 136799 | — |
Reaction Steps
10.0 g (50.7 mmols) of N,N-di(p-toluyl)amine (31b), 10.3 g (50.7 mmols) of 4-iodobenzene, 5.85 g (60.8 mmols) of t-BuONa, 300 mg (1.34 mmols) of Pd(CH3CO)2 and 1.50 g (5.71 mmols) of triphenylphosphine were dissolved in xylene and refluxed in an atmosphere of nitrogen for 4 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06979746B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-7e8279a1378644438bc871a4a81240f4 |
| Source note | uspto-grants-2005_12 |