Ethanethioic acid, S-(2-(((2R)-2-(acetylamino)-3-mercapto-1-oxopropyl)amino)ethyl)ester → HCID 516557, compound

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Reaction Steps

This compound is obtained by the S-detritylation of 12 (4.44 mmol). The protocol used is the same as that described in example 1 for the synthesis of I-152. After the various treatments, a gum is collected, which gum is purified by flash chromatography on a silica gel column (eluent: AcOEt/petroleum ether 50%). I-198 is isolated in the form of a white solid with a yield of 63%. Rf CH2Cl2/MeOH, 9.5/0.5): 0.38. M.p.=128-130° C. [α]D20=−24.7° (c 1.01, CHCl3).

Provenance & Evidence