Ethanethioic acid, S-(2-(((2R)-2-(acetylamino)-3-mercapto-1-oxopropyl)amino)ethyl)ester → HCID 86593958, compound

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Reaction Steps

This compound is obtained by the S-detritylation of 14 (2.56 mmol). The protocol used is the same as that described in example 1 for the synthesis of I-152. After the various treatments, a gum is collected, which gum is purified by flash chromatography on a silica gel column (eluent: CH2Cl2/ether 30%). I-203 is isolated in the form of white solid with a yield of 70%. Rf CH2Cl2/ether, 5/5): 0.44. M.p.=117-120° C. [α]D20=−36.5° (c 1.04, CHCl3).

Provenance & Evidence