HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → HCID 86593963, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Ethanethioic acid, S-(2-(((2R)-2-(acetylamino)-3-mercapto-1-oxopropyl)amino)ethyl)ester | HCID 484333 | — |
| Reactant | Ethyl ether methylene chloride | HCID 21881112 | — |
| Reactant | HCID 56984260 | HCID 56984260 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | HCID 86593963 | HCID 86593963 | — |
Reaction Steps
This compound is obtained by the S-detritylation of 17 (2.68 mmol). The protocol used is the same as that described in example 1 for the synthesis of I-152. After the various treatments, a gum is collected, which gum is purified by flash chromatography on a silica gel column (eluent: CH2Cl2/ether 25%). I-219 is isolated in the form of a gum which, after trituration in hexane, provides a colorless powder (Yd=58%). Rf (CH2Cl2/ether, 6/4): 0.35. M.p.=127-130° C. [α]D20=−20.8° (c 1.06, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06979747B2 |
| Source dataset | uspto-grants-2005_12 |
| ORD ID | ord-491015591857461e90781c6f2f55e982 |
| Source note | uspto-grants-2005_12 |