Hydrochloric Acid → HCID 69694571, compound

Participants

Reaction Conditions

Reaction Steps

[1,4′]Bipiperidinyl-3,1′-dicarboxylic acid 1′-tert-butyl ester 3-ethyl ester (21.14 g, containing some isopropyl ester) was dissolved in ethyl acetate (80 mL) under nitrogen, cooled to −78° C. and hydrogen chloride passed in for several minutes until the solution became saturated. The solution was allowed to warm to ambient temperature with provision for the evolved gases to be trapped by water in a scrubber. After 3 hr the solution was evaporated to dryness in a stream of dry nitrogen to give the title compound as a white solid.

Provenance & Evidence