Pyruvic Acid → HCID 5183222, compound

Participants

Reaction Steps

4-Trifluoromethylaniline (0.015 mmol, 1.88 mL), pyruvic acid (1.0 eq, 0.015 mmol, 2.04 mL) and 4-trifluoromethylbenzaldehyde were dissolved in acetic acid (10 mL). Concentrated sulfuric acid (10 mL) was cautiously added (exothermic) and stirred for 30 minutes. Chloroform (50 mL) and water (50 mL) were added followed by ammonium hydroxide until the solution was basic to pH paper. The layers were separated and the aqueous solution was extracted with chloroform (3×50 mL). The combined organic layers were dried over anhydrous sodium sulfate and the solvent was evaporated under vacuum. The solid residue was purified by recrystallization from 95% ethanol to give the title compound as a yellow solid (580 mg, 10%).

Provenance & Evidence