HCID 86589866, compound → HCID 69694538, compound

Participants

Reaction Steps

1′-(Anthracene-9-carbonyl)-5,6,1′,2′,3′,4′,5′,6′-octahydro-4H-[1,4′]bipyridinyl-3-carboxylic acid diethylamide (0.033 mmol, 15.5 mg) was dissolved in methanol (˜20 mL), 10% palladium on carbon (10% w/w) (30 mg) was added and the suspension was shaken under a hydrogen atmosphere (45 psi) for 42 h at room temperature in a Parr shaker. The catalyst was filtered off, the solvent evaporated and the residue was purified by chromatography on silica gel eluting with a 1%-5% methanol-dichloromethane gradient to give the title compound (5.3 mg, 34%).

Provenance & Evidence