反应详情

A mixture of ethyl 5-amino-1,2-benzisothiazole-3-acetate (0.748 g, 3.16 mmol) and 2-dimethylamino-4-(trifluoromethyl)-6H-1,3-oxazin-6-one (0.660 g, 3.17 mmol) in acetic acid is refluxed for three hours, concentrated in vacuo, and diluted with saturated sodium hydrogen carbonate solution. The resultant mixture is extracted with methylene chloride. The combined organic extracts are washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to give the title product as a tan solid which is identified by NMR spectral analysis.

1. temperatureis refluxed for three hours
2. concentrationconcentrated in vacuo
3. additiondiluted with saturated sodium hydrogen carbonate solution
4. extractionThe resultant mixture is extracted with methylene chloride
5. washThe combined organic extracts are washed with water
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated in vacuo