反应详情

2.17 g of 3-(trichloromethyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole was added to 50 ml of methanol. An excess of ammonia gas was added with formation of bubble at 0° C. and then the mixture was stirred at room temperature for 4 hours. After evaporation of methanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(hexane:ethylacetate) to provide 0.92 g of the desired product(yield: 50.9%).

1. customof bubble at 0° C.
2. customAfter evaporation of methanol, water
3. additionwas added to the residue
4. extractionThe aqueous solution was extracted with ethylacetate
5. customAfter evaporation of ethylacetate
6. customthe residue was purified by column chromatography(hexane:ethylacetate)