HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-4-(5-nitropyridin-2-yl)piperazine → 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-4-(5-nitropyridin-2-yl)piperazine | HCID 2848980 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine | HCID 9161674 | 102.8% |
Reaction Steps
A mixture of 2.47 g (10 mmol) 1-ethyl-4-(5-nitro-pyridin-2-yl)-piperazine and 0.247 g Pd/C (10%) in 25 ml methanol was treated with 1 bar hydrogen at room temperature for 2 h. After filtration the mixture was evaporated to dryness to yield 2.12 g (98%) of the title compound as colorless solid. (m/e): 207.3 (MH+; 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528135B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-a1e7d8f893064257afae504bc759d0f1 |
| Source note | uspto-grants-2009_05 |