HCID 69001720, compound → HCID 178434270, compound

Participants

Reaction Steps

A solution of 6-amino-3-[N-(4-methoxybenzyl)-3-methylindazol-5-yl]-5-(4-Boc-piperazin-1-yl)-[1,2,4]triazine 111 (0.016 g, 0.0302 mmol) in trifluoroacetic acid (2.5 mL) was heated in a microwave reactor at 120° C. for 40 minutes. The organic solvent was evaporated under reduced pressure. Methanol (1 mL) and dichloromethane (9 mL) were added. The organic solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 6-amino-3-(3-methylindazol-5-yl)-5-(piperazin-1-yl)-[1,2,4]triazine 1 (0.008 g, 0.0259 mmol).

Provenance & Evidence