Trifluoroacetic acid → HCID 178434266, compound

Participants

Reaction Steps

To a solution of 3-(3-methylindazol-5-yl)-5-[(S)-4-Boc-3-benzylpiperazin-1-yl]-[1,2,4]triazine 124 (0.012 g, 0.025 mmol) was added a solution of trifluoroacetic acid in dichloromethane (20% v/v, 2 mL). The reaction mixture was stirred at room temperature for 1 hour. The organic solvent was evaporated under reduced pressure. Methanol (1 mL) and dichloromethane (9 mL) were added. The organic solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 3-(3-methylindazol-5-yl)-5-[(S)-3-benzylpiperazin-1-yl]-[1,2,4]triazine 12 (0.0041 g, 0.0106 mmol).

Provenance & Evidence