Trifluoroacetic acid → HCID 178434259, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(4-Boc-piperazin-1-yl)-3-[N-(4-methoxybenzyl)-3-methylindazol-5-yl]-6-phenethyl-[1,2,4]triazine 129 (18 mg, 0.029 mmol.) was added trifluoroacetic acid (2.5 mL). The reaction mixture was heated in a microwave reactor at 120° C. for 40 minutes. Excess trifluoroacetic acid was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 3-(3-methylindazol-5-yl)-6-phenethyl-5-(piperazin-1-yl)-[1,2,4]triazine 92 (8.5 mg, 0.021 mmol.).

Provenance & Evidence