反应详情

In 3 ml of pyridine, 1 mmol of 5-amino-2-chlorobenzenesulfonamide and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 90-100° C. for 9 hours. Pyridine was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue. After the mixture thus formed was stirred for 20 minutes, the resulting precipitate was collected by filtration and then dried in air. Yield: 93%. Its physicochemical properties are shown in Table 8.

1. distillationPyridine was then distilled off from the reaction mixture
2. additionfollowed by the addition of 20 ml of ice water and 0.1 ml of 35% hydrochloric acid to the solid residue
3. customAfter the mixture thus formed
4. filtrationthe resulting precipitate was collected by filtration
5. customdried in air