Formaldehyde → HCID 178434263, compound

Participants

Reaction Steps

To a solution of 5-[(S)-3-benzylpiperazin-1-yl]-3-(3-methylindazol-5-yl)-[1,2,4]triazine 12 (14 mg, 0.036 mmol.) in 10% methanolic acetic acid was added 37% aqueous formaldehyde solution (0.06 mL, 0.74 mmol.) and cyanoborohydride resin (2.42 equiv./g, 44 mg, 0.11 mmol.). The reaction mixture was stirred at room temperature for 5 hours. The reaction mixture was filtered and the filtrate was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 5-[(S)-3-benzyl-4-methyl-piperazin-1-yl]-3-(3-methylindazol-5-yl)-[1,2,4]triazine 28 (7.1 mg, 0.018 mmol.).

Provenance & Evidence