Potassium Hydroxide → HCID 11622988, compound

Participants

Reaction Steps

A solution of 2-amino-3-pyridin-2-yl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester (1.58 g, 5.58 mmol) and potassium hydroxide (0.95 g, 16.7 mmol) in ethanol (30 mL) was refluxed for 3 h, then cooled down to room temperature. The precipitate was filtered off, washed with ether, suspended in ether, treated with 2M HCl/Et2O (15 mL, 30 mmol), stirred 0.5 h, and filtered, washing with ether to provide an HCl salt of the title compound as a brown solid (0.88 g, 54% yield). MS (ES+) 256. δH (500 Mhz, DMSO-d6) 7.25 (1H, m), 7.94 (1H, t), 8.56 (1H, d), 8.60 (1H, d), 8.83 (1H, d), 9.16 (1H, d).

Provenance & Evidence