Trifluoroacetic acid → (2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine trifluoroacetate

Beteiligte Stoffe

Reaktionsschritte

10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.20 g of the compound obtained in step 7-2, after which the reaction mixture was stirred for 2 hours at room temperature. After this, the reaction mixture was concentrated under reduced pressure to obtain 3.82 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.

Herkunft & Nachweise