2-Chloro-N-(2,6-dimethylphenyl)acetamide → HCID 68872866, compound

HRID 490182Notes

Reaction equation

HRID 490182 reaction equation
F[C:2](F)(F)C(O)=O.[NH:8]1[CH2:13][CH:12]=[C:11]([C:14]2[S:15][CH:16]=[CH:17][C:18]=2[C:19]#[N:20])[CH2:10][CH2:9]1.Cl[CH2:22][C:23]([NH:25][C:26]1[C:31](C)=[CH:30][CH:29]=[CH:28][C:27]=1C)=[O:24]>>[C:19]([C:18]1[CH:17]=[CH:16][S:15][C:14]=1[C:11]1[CH2:10][CH2:9][N:8]([CH2:22][C:23]([NH:25][C:26]2[CH:27]=[CH:28][CH:29]=[C:30]([CH3:2])[CH:31]=2)=[O:24])[CH2:13][CH:12]=1)#[N:20]

Participants

3

Reactant 2

HCID 707982-Chloro-N-(2,6-dimethylphenyl)acetamideHCID 68876319HCID 68876319, compound

Product 1

HCID 68872866HCID 68872866, compound

Procedure

The desired material was prepared according to the procedure of Example 145 by substituting the product from Example 143B with the product from Example 155A, and 2-chloro-N-(2,6-dimethylphenyl)acetamide with the product from Example 33A. Yield 13 mg (36%). 1H NMR (300 MHz, DMSO-d6) δ 2.30 (s, 3H), 2.90 (m, 2H), 3.50-4.20 (m, 4H), 4.30 (s, 2H), 6.43 (br s, 1H), 6.98 (m, 1H), 7.24 (m, 1H), 7.42 (m, 2H), 7.50 (m, 1H), 7.78 (m, 1H), 10.42 (m, 1H), 10.44 (br s, 1H); MS (ESI/APCI+) m/e 338 (M+H)+.

Sources & evidence

ORD record
ord-3b6c36daccb346bdb44226f15ba528bc
Source dataset
uspto-grants-2009_05
Patent number
US07528134B2

Reaction notes

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