1-(2,4,5-Trifluorophenyl)piperazine → 8-[(2R)-1-[4-(2,4,5-trifluorophenyl)piperazin-1-yl]propan-2-yl]-8-azaspiro[4.5]decane-7,9-dione

HRID 49023Notes

Reaction equation

HRID 49023 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.Cl[CH2:17][C@H:18]([N:20]1[C:29](=[O:30])[CH2:28][C:23]2([CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:22][C:21]1=[O:31])[CH3:19]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[N:10]1[CH2:11][CH2:12][N:13]([CH2:19][C@H:18]([N:20]2[C:29](=[O:30])[CH2:28][C:23]3([CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:22][C:21]2=[O:31])[CH3:17])[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 113218821-(2,4,5-Trifluorophenyl)piperazineHCID 11322499(R)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione

Product 1

HCID 98451818-[(2R)-1-[4-(2,4,5-trifluorophenyl)piperazin-1-yl]propan-2-yl]-8-azaspiro[4.5]decane-7,9-dioneYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
160 °C

Procedure

A mixture of 1-(2,4,5-trifluorophenyl)piperazine (105 mg, 0.49 mmol) and (R)-8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione (105 mg, 0.43 mmol) was heated with stirring at 160° C. for 5 hours. The residue was dissolved in methanol, transferred to a preparative thin layer chromatographic plate (silica gel), and eluted with ethyl acetate/hexane (1:1). A band at Rf=0.8 was removed and rinsed with chloroform/methanol (4:1). The solvent was removed, giving the title compound as a pale yellow oil (86.2 mg, 0.20 mmol, 47%). 1H NMR (300 MHz, CDCl3) δ6.89 (ddd, 1H, J=11.7, 10.2, 7.5 Hz), 6.71 (dt, 1H, J=12.0, 8.1 Hz), 5.08-4.96 (m, 1H), 3.14 (dd, 1H, J=12.6, 10.5 Hz), 2.92 (t, 4H, J=4.7 Hz), 2.73-2.66 (m, 2H), 2.58 (s, 4H), 2.51-2.44 (m, 2H), 2.36 (dd, 1H, J=12.6, 5.4 Hz), 1.75-1.68 (m, 4H), 1.57-1.50 (m, 4H), 1.34 (d, 3H, J=6.9 Hz); ESI-MS m/z 424 (MH+). The title compound was dissolved in ether and precipitated by addition of 1N HCl in ether, giving a white solid: mp 231-235° C.

Workup

  1. temperaturewas heated
  2. washeluted with ethyl acetate/hexane (1:1)
  3. customA band at Rf=0.8 was removed
  4. washrinsed with chloroform/methanol (4:1)
  5. customThe solvent was removed

Sources & evidence

ORD record
ord-1a2199d3939749fa828a29abc5e34276
Source dataset
uspto-grants-2004_03
Patent number
US06706716B2

Reaction notes

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