Water → HCID 22711812, compound

Participants

Reaction Conditions

Reaction Steps

NaBH4 (0.034 mol) was added portionwise at 5° C. to a mixture of (±)-1,1-dimethylethyl 4-[[1-(2-oxo-2-phenylethyl)-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate (0.034 mol) in tetrahydrofuran (250 ml) and methanol (250 ml). The mixture was stirred at 5° C. and then hydrolyzed cold with H2O. The solvent was evaporated and the residue was taken up in H2O. The precipitate was filtered off, washed with diisopropylether and dried, yielding 11.3 g of (±)-1,1-dimethylethyl 4-[[1-(2-hydroxy-2-phenylethyl)-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate (76%) (interm. 3).

Provenance & Evidence