HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-(Benzyloxy)-6-methylpyridin-2-yl)methanol → 3-(Benzyloxy)-6-methylpicolinaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-(Benzyloxy)-6-methylpyridin-2-yl)methanol | HCID 22711808 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(Benzyloxy)-6-methylpicolinaldehyde | HCID 22711775 | 94% |
Reaction Steps
A mixture of 3-(benzyloxy)-6-methyl-2-pyridinemethanol (0.0314 mol) and MnO2 (29.52 g) in CH2Cl2 (100 ml) was stirred at room temperature overnight and then purified over silica gel on a glass filter (eluent: CH2Cl2 100%). The pure fractions were collected and the solvent was evaporated, yielding 6.71 g of 6-methyl-3-(phenylmethoxy)-2-pyridinecarboxaldehyde (94%) (interm. 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528149B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-436eb99919514c43aead883d56785d27 |
| Source note | uspto-grants-2009_05 |