HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methyl-5-nitroisoquinoline → 3-Methylisoquinolin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methyl-5-nitroisoquinoline | HCID 274973 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Methylisoquinolin-5-amine | HCID 12212055 | 76.1% |
Reaction Steps
A solution of (D1) (1 g, 5.3 mM) and 10% palladium on charcoal (0.15 g) in methanol (40 ml) was hydrogenated at atmospheric pressure for 1 h. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the product as a grey solid (0.64 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528150B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-75455a89fbf143aba118e50ac228915c |
| Source note | uspto-grants-2009_05 |