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HRID 49029作成日：2026年10月25日
1-(3,4-Difluorophenyl)piperazine → 8-{2-[4-(3,4-Difluorophenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione
https://huagongshe.com/reaction/49029
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(3,4-Difluorophenyl)piperazine | HCID 2783122 | — |
| 反応物 | 8-(2-Chloroethyl)-8-azaspiro[4.5]decane-7,9-dione | HCID 11481612 | — |
| 生成物 | 8-{2-[4-(3,4-Difluorophenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione | HCID 9865254 | 40.2% |
反応手順
A mixture of 1-(3,4-difluorophenyl)piperazine (21.5 mg, 0.109 mmol) and 8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione(20 mg, 0.087 mmol) was heated with stirring at 165° C. for 1 hour. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (13.7 mg, 0.035 mmol, 40%): ESI-MS m/z 392 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06706716B2 |
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| 出典データセット | uspto-grants-2004_03 |
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| ORD ID | ord-e3accd28538d41f4a2ac17b3f2cf071c |
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| 出典メモ | uspto-grants-2004_03 |
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