4-(N-Boc-amino)piperidine → 1-(5-(Trifluoromethyl)pyridin-2-yl)piperidin-4-amine

HRID 490296Notes

Reaction equation

HRID 490296 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)(C)(C)C.C(OC(=O)N[C@@H]1CCN([C:27]2[C:32]([C:33]([F:36])([F:35])[F:34])=[CH:31][CH:30]=[CH:29][N:28]=2)C1)(C)(C)C.FC(F)(F)C1C(N2CC[C@@H](N)C2)=NC=CC=1>>[F:34][C:33]([F:36])([F:35])[C:32]1[CH:31]=[CH:30][C:29]([N:11]2[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]2)=[N:28][CH:27]=1

Participants

4

Reactant 3

HCID 7238334-(N-Boc-amino)piperidineHCID 67001808[(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl esterHCID 68801104(R)-1-(3-Trifluoromethylpyridin-2-yl)pyrrolidin-3-ylamine

Product 1

HCID 47782341-(5-(Trifluoromethyl)pyridin-2-yl)piperidin-4-amine

Procedure

The title compound was prepared from D7 and 2-chloro-5-ifluoromethylpyridine using the procedure outlined for Descriptions D1 and D2.

Sources & evidence

ORD record
ord-da58078f16dd4eb9a3636dbb92b2905f
Source dataset
uspto-grants-2009_05
Patent number
US07528151B2

Reaction notes

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