Potassium Carbonate → Tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)carbamate

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-(N-Boc-amino)piperidine	HCID 723833	—
반응물	2,5-dichloro-3-(trifluoromethyl)pyridine	HCID 11042144	—
용매	Water	HCID 962	—
생성물	Tert-butyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)carbamate	HCID 2796148	93.8%

반응 조건

온도	120 °C

반응 단계

A stirred suspension of D7 (5.5 g, 27.5 mmol), 3,6-dichloro-5-trifluoromethylpyridine (3.83 mL, 27.5 mmol) (for synthesis see Tetrahedron, 1985, 41, 4057) and potassium carbonate (11.4 g, 82.6 mmol) in dry N,N-DMF (100 mL) was heated at 120° C. for 24 h. After cooling to ambient temperature, the mixture was poured into water (1 L), stirred for 1 h and then filtered. The residue was washed with water (3×150 mL and dried (MgSO4) to afford the title compound (9.8 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07528151B2
출처 데이터셋	uspto-grants-2009_05
ORD ID	ord-855bff68ee5b4c99a0fe01f282118e39
출처 메모	uspto-grants-2009_05