4-(N-Boc-amino)piperidine → 1-(4-Trifluoromethylpyrimidin-2-yl)piperidin-4-ylamine

HRID 490301Notes

Reaction equation

HRID 490301 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)(C)(C)C.Cl[C:16]1[N:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][N:17]=1>>[F:23][C:22]([F:25])([F:24])[C:20]1[CH:19]=[CH:18][N:17]=[C:16]([N:11]2[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]2)[N:21]=1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

Product 1

HCID 27961221-(4-Trifluoromethylpyrimidin-2-yl)piperidin-4-ylamine

Procedure

The title compound was prepared from D7 and 2-chloro-4-trifluoromethyl-pyrimidine using the procedure outlined for Descriptions D11 and D12.

Sources & evidence

ORD record
ord-b65cdb00bdfd4d2db950b7bc17803b9e
Source dataset
uspto-grants-2009_05
Patent number
US07528151B2

Reaction notes

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