HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-nitro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate → 6-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-nitro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate | HCID 67082761 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate | HCID 11507344 | — |
Reaction Steps
30 mg (0.1 mmol) of 6-nitro-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate (Example 5B) in 15 ml of ethanol were hydrogenated in the presence of 10% palladium/carbon under a hydrogen pressure of 2 bar at room temperature for 2.5 h. The catalyst was filtered off with suction, and the filtrate was concentrated. Yield: 21 mg (76%), M+H+: 275.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528155B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-3e775771a57d40f68ffd3f8c572af320 |
| Source note | uspto-grants-2009_05 |