Sodium Sulfite → HCID 178518961, compound

Participants

Reaction Steps

2-Amino-4-fluorobenzoic acid (25 g, 161.2 mmol) were suspended in 250 ml of water and 39 ml of conc. hydrochloric acid. At 0° C., sodium nitrite (11.2 g, 161.2 mmol) in 30 ml of water were added dropwise at below 10° C. After 30 min at room temp., sodium sulfite (69 g, 400 mmol) in 250 ml of water were added. After stirring for 2 h, 30 ml of conc. hydrochloric acid were added, and the mixture was left to stand overnight. It was then heated under reflux for 9 h, cooled and adjusted to pH 5.5 with sodium bicarbonate. The precipitate was filtered off with suction and dried.

Provenance & Evidence