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HRID 490331作成日：2026年10月26日
1-[(3,4-Dichlorophenyl)methyl]piperidin-4-amine → N-(2-{3-[1-(3,4-Dichloro-benzyl)-piperidin-4-ylamino]-2-hydroxy-propoxy}-phenyl)-benzamide
https://huagongshe.com/reaction/490331
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-[(3,4-Dichlorophenyl)methyl]piperidin-4-amine | HCID 10978156 | — |
| 反応物 | N-(2-Oxiranylmethoxy-phenyl)-benzamide | HCID 22386962 | — |
| 生成物 | N-(2-{3-[1-(3,4-Dichloro-benzyl)-piperidin-4-ylamino]-2-hydroxy-propoxy}-phenyl)-benzamide | HCID 10119159 | — |
反応手順
To a solution of N-(2-Oxiranylmethoxy-phenyl)-benzamide (0.2 ml, 0.1M in DMSO) was added (0.2 ml, 0.1M in EtOH) of 1-(3,4-Dichloro-benzyl)-piperidin-4-ylamine. The resulting mixture was heated at 75-80° C. for 24 hours. The ethanol was removed and the product was purified with preparative LC/MS.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07528156B2 |
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| 出典データセット | uspto-grants-2009_05 |
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| ORD ID | ord-3692184fbfc34874a1c0c3e8545c809a |
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| 出典メモ | uspto-grants-2009_05 |
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