Ammonia → 3-(Morpholin-4-yl)propane-1-sulfonamide

HRID 490357Notes

Reaction equation

HRID 490357 reaction equation
[NH3:1].C(=O)=O.CC(C)=O.[N:9]1([CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>ClCCl>[N:9]1([CH2:15][CH2:16][CH2:17][S:18]([NH2:1])(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 18522661Acetone cardiceHCID 219731893-Morpholinopropane-1-sulfonyl chloride

Product 1

HCID 214771353-(Morpholin-4-yl)propane-1-sulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dichloromethane (40 ml) was saturated with ammonia gas with cooling (dry ice/acetone), and then 3-morpholin-4-yl-propane-1-sulphonyl chloride (279 mg, 1.23 mmoles) was added. The mixture was stirred at room temperature for 24 hours. The mixture was filtered, the filtrate evaporated and the residue was dried at 40° C. in vacuo to afford compound 58 (210 mg) as a gum. LC/MS System A; Rt=0.28 mins, m/z (ES+)=209 (M+H for C7H16N2O3S).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated
  3. customthe residue was dried at 40° C. in vacuo

Sources & evidence

ORD record
ord-dc6daf353b524388bfa92a83a2bcf80f
Source dataset
uspto-grants-2009_05
Patent number
US07528157B2

Reaction notes

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