2,3,4-Trichloronitrobenzene → 4-Carbobenzyloxy-1-(5,6-dichloro-2-nitrophenyl)piperazine-2-carboxylic acid

HRID 49037Notes

Reaction equation

HRID 49037 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[C:13]([N:23]1[CH2:28][CH2:27][NH:26][CH:25]([C:29]([OH:31])=[O:30])[CH2:24]1)([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]>>[C:13]([N:23]1[CH2:28][CH2:27][N:26]([C:2]2[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=2[N+:10]([O-:12])=[O:11])[CH:25]([C:29]([OH:31])=[O:30])[CH2:24]1)([O:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:14]

Participants

3

Reactant 2

HCID 286972,3,4-TrichloronitrobenzeneHCID 50583624-((Benzyloxy)carbonyl)piperazine-2-carboxylic acid

Product 1

HCID 219766874-Carbobenzyloxy-1-(5,6-dichloro-2-nitrophenyl)piperazine-2-carboxylic acidYield 43.6%

Procedure

By the same procedure described for Example 7 A, from 0.86 g of 2,3,4-trichloro-nitro-benzene and 1.0 g of 4-carbobenzyloxypiperazine-2-carboxylic acid, there was obtained 0.75 g of the desired product as a brown oil.

Sources & evidence

ORD record
ord-fabb7311f562439b82a73e4d38dda136
Source dataset
uspto-grants-2004_03
Patent number
US06706714B2

Reaction notes

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