(3-hydroxyphenyl)boronic Acid → 4-(3'-Hydroxy-biphenyl-4-yloxymethyl)-5-methyl-furan-2-carboxylic acid

HRID 490376Notes

Reaction equation

HRID 490376 reaction equation
I[C:2]1[CH:18]=[CH:17][C:5]([O:6][CH2:7][C:8]2[CH:9]=[C:10]([C:14]([OH:16])=[O:15])[O:11][C:12]=2[CH3:13])=[CH:4][CH:3]=1.[OH:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[OH:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:18]=[CH:17][C:5]([O:6][CH2:7][C:8]3[CH:9]=[C:10]([C:14]([OH:16])=[O:15])[O:11][C:12]=3[CH3:13])=[CH:4][CH:3]=2)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 2734359(3-hydroxyphenyl)boronic AcidHCID 184446544-(4-Iodo-phenoxymethyl)-5-methyl-furan-2-carboxylic acid

Product 1

HCID 184445534-(3'-Hydroxy-biphenyl-4-yloxymethyl)-5-methyl-furan-2-carboxylic acid

Procedure

Compound (112) was prepared from compound (26) and (3-hydroxy-phenyl)-boronic acid by adapting the procedure of Example 27A. LC/MS System B; Rt=1.23 mins, m/z (ES−)=323 (M−H for C19H16O5).

Sources & evidence

ORD record
ord-878357c213b741968563b53b030a2e1e
Source dataset
uspto-grants-2009_05
Patent number
US07528157B2

Reaction notes

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