Potassium Hydroxide → HCID 67147507, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-[4-(3-{5,6-dimethoxy-3-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]indol-1-yl}propyl)piperazin-1-yl]ethanol trifluoroacetate (0.038 g; 52.2 μmol) in a methanolic potassium hydroxide solution (3 ml, 0.1 g of potassium hydroxide per ml of methanol) is placed in a hemolysis tube (1.3×10 cm) and is agitated at 20° C. for 72 hours. The solid form is filtered off and then purified by reverse-phase liquid chromatography mass spectrometry (method E). The fractions containing the expected compound are combined and then evaporated under reduced pressure, giving 2-(4-{3-[5,6-dimethoxy-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)indol-1-yl]propyl}piperazin-1-yl)ethanol trifluoroacetate (0.022 g; 90%), the characteristics of which are as follows:

Provenance & Evidence