HCID 67147440, compound → HCID 67147607, compound

HRID 490420Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH2:14][CH2:15][CH2:16][N:17]1[CH2:23][CH2:22][CH2:21][N:20]([CH3:24])[CH2:19][CH2:18]1)[CH:7]=[C:6]2[C:25]1[NH:33][C:28]2=[N:29][CH:30]=[CH:31][CH:32]=[C:27]2[CH:26]=1.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].COC1C=C2C(=CC=1OC)N(CCCN1CCCN(C)CC1)C=C2C1N(S(C2C=CC(C)=CC=2)(=O)=O)C2=NC=CC=C2C=1>>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH2:14][CH2:15][CH2:16][N:17]1[CH2:23][CH2:22][CH2:21][N:20]([CH3:24])[CH2:19][CH2:18]1)[CH:7]=[C:6]2[C:25]1[NH:33][C:28]2=[N:29][CH:30]=[CH:31][CH:32]=[C:27]2[CH:26]=1

Participants

Reactant 2

HCID 67147440HCID 67147440, compound

HCID 67147559HCID 67147559, compound

Product 1

HCID 67147607HCID 67147607, compoundYield 45%

Procedure

2-{5,6-Dimethoxy-1-[3-(4-methylperhydro-1,4-diazepin-1-yl)propyl]-1H-indol-3-yl}-1H-pyrrolo[2,3-b]pyridine can be prepared in the same way as above (example 82a), but using 2-{5,6-dimethoxy-1-[3-(4-methylperhydro-1,4-diazepin-1-yl)propyl]-1H-indol-3-yl}-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine trifluoroacetate, (0.053 g, 63.9 μmol). 2-{5,6-dimethoxy-1-[3-(4-methylperhydro-1,4-diazepin-1-yl)propyl]-1H-indol-3-yl}-1H-pyrrolo[2,3-b]pyridine trifluoroacetate (0.023 g, 45%) is thus obtained, the characteristics of which are as follows:

Sources & evidence

ORD record: ord-e303cfe7e26247ae9f176d8ec11a70fc
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07528147B2

Reaction notes

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