Tetrabutylammonium Fluoride → HCID 67147466, compound

Participants

Reaction Steps

3-{5,6-Dimethoxy-3-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]indol-1-yl}propanol and 2-[5,6-dimethoxy-1-(3-fluoropropyl)indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine are prepared by following the procedure described in example 89b, but using 0.605 g of 2-[5,6-dimethoxy-1-(3-tert-butyldimethylsilyloxypropyl)indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine and 1.95 ml of tetrabutylammonium fluoride (TBAF). After purification by flash chromatography (silica, 98/02 by volume dichloromethane/methanol as eluents, argon), 0.243 g of 3-{5,6-dimethoxy-3-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]indol-1-yl}propanol is obtained, the characteristics of which are as follows:

Provenance & Evidence