Potassium Hydroxide → HCID 11638529, compound

Participants

Reaction Steps

A suspension of 0.14 g of 2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile in 1.3 ml of a 5 N aqueous potassium hydroxide solution and 5 ml of methanol is brought to a temperature in the region of 60° C. for approximately 30 minutes. After returning to around 20° C., the insoluble material is filter-dried, and washed with water until a neutral pH is obtained. The insoluble material is purified by flash chromatography on a silica column [eluent: dichloromethane/methanol (98/2 by volume)]. 0.05 g of 2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile is obtained in the form of a solid, the characteristics of which are as follows:

Provenance & Evidence