反应详情

温度

20 °C

A solution of 0.54 g of 4-chloro-2-[5,6-dimethoxy-1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine and 1.8 g of potassium hydroxide in 18 ml of methanol is brought to around 60° C. for approximately 2 hours. After cooling to approximately 20° C., the precipitate is filter-dried, washed with two times 3 ml of methanol and three times 5 ml of water, and then dried in an oven under reduced pressure (13 kPa) at a temperature in the region of 40° C. for approximately 8 hours. 0.241 g of 4-chloro-2-[5,6-dimethoxy-1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is obtained in the form of a solid, the characteristics of which are as follows:

1. customthe precipitate is filter-dried
2. washwashed with two times 3 ml of methanol and three times 5 ml of water
3. customdried in an oven under reduced pressure (13 kPa) at a temperature in the region of 40° C. for approximately 8 hours