Potassium Hydroxide → HCID 67147505, compound

HRID 490477Notes

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:20][CH3:21])=[C:8]([O:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[CH:9]=2)[C:4]([C:22]2[N:30](S(C3C=CC(C)=CC=3)(=O)=O)[C:25]3=[N:26][CH:27]=[CH:28][CH:29]=[C:24]3[CH:23]=2)=[CH:3]1.[OH-].[K+]>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:20][CH3:21])=[C:8]([O:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[CH:9]=2)[C:4]([C:22]2[NH:30][C:25]3=[N:26][CH:27]=[CH:28][CH:29]=[C:24]3[CH:23]=2)=[CH:3]1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 67147475HCID 67147475, compound

Product 1

HCID 67147505HCID 67147505, compoundYield 66.7%

Procedure

2-[1-Methyl-5-methoxy-6-(2-morpholin-4-yl-ethoxy)-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is prepared by following the procedure described in example 89a, but using 0.24 g of 2-[1-methyl-5-methoxy-6-(2-morpholin-4-ylethoxy)-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine and 1.93 ml of a 5N aqueous potassium hydroxide solution. 0.116 g of 2-[1-methyl-5-methoxy-6-(2-morpholin-4-ylethoxy)-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is obtained, the characteristics of which are as follows:

Workup

custom2-[1-Methyl-5-methoxy-6-(2-morpholin-4-yl-ethoxy)-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is prepared

Sources & evidence

ORD record: ord-809783fb33b44b6aac4aae8d90c84773
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07528147B2

Reaction notes

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