Potassium Hydroxide → HCID 67147596, compound

HRID 490490Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]([CH3:13])[CH:7]=[C:6]2[C:14]1[N:22](S(C2C=CC(C)=CC=2)(=O)=O)[C:17]2=[N:18][CH:19]=[CH:20][CH:21]=[C:16]2[CH:15]=1.[OH-].[K+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]([CH3:13])[CH:7]=[C:6]2[C:14]1[NH:22][C:17]2=[N:18][CH:19]=[CH:20][CH:21]=[C:16]2[CH:15]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 67147629HCID 67147629, compound

Product 1

HCID 67147596HCID 67147596, compoundYield 54.6%

Procedure

2-(5-Methoxy-1,6-dimethyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]-pyridine is prepared by following the procedure described in example 189a, but using 0.028 g of 2-(5-methoxy-1,6-dimethyl-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine and 0.283 ml of a 5N aqueous potassium hydroxide solution. 0.01 g of 2-(5-methoxy-1,6-dimethyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]-pyridine is obtained, the characteristics of which are as follows:

Workup

custom2-(5-Methoxy-1,6-dimethyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]-pyridine is prepared

Sources & evidence

ORD record: ord-c800657ae18b4771b4e5152bc2a51019
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07528147B2

Reaction notes

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