反应详情

温度

40 °C

To a solution of 1-isobutyl-5-nitro-1,2-dihydro-indazol-3-one (0.9 g) in MeOH (50 mL) was added Pd/C(10%) catalyst (0.3 g) and the reaction mixture was stirred for 1 hour at 40° C. under a hydrogen atmosphere using a balloon. After this time the reaction mixture was filtered through Celite® which was washed with more EtOAc. The combined organic solution was evaporated in vacuo for afford the desired 5-amino-1-isobutyl-1,2-dihydro-indazol-3-one (0.6 g) which was taken into the next reaction without further purification. MS (ESI+): 206.1 ([M+H]+).

1. filtrationAfter this time the reaction mixture was filtered through Celite® which
2. washwas washed with more EtOAc
3. customThe combined organic solution was evaporated in vacuo