HCID 68836725, compound → HCID 68833576, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(4-fluoro-benzyl)-5-nitro-1,2-dihydro-indazol-3-one (0.81 g) in MeOH (100 mL) was added Pd/C(10%) catalyst (0.1 g) and the reaction mixture was stirred for three hours at 40° C. under a hydrogen atmosphere using a balloon. After this time the reaction mixture was filtered through Celite® which was washed with more EtOAc. The combined organic solution was evaporated in vacuo for afford the desired 5-amino-1-(4-fluoro-benzyl)-1,2-dihydro-indazol-3-one (0.617 g) which was taken into the next reaction without further purification. MS (ESI+): 258.3 ([M+H]+).

Provenance & Evidence