Hydrochloric Acid → HCID 68834593, compound

Participants

Reaction Steps

To a solution of (5-nitro-3-oxo-2,3-dihydro-indazol-1-yl)-acetic acid ethyl ester (0.24 g) in THF (9 mL), was added 2 N NaOH (aq.) (1.8 mL). The reaction mixture was stirred at ambient temperature for 30 minutes. The reaction mixture was acidified with 2 N HCl (aq.) and extricated with EtOAc. Evaporation of the organic phases afforded the desired crude (5-nitro-3-oxo-2,3-dihydro-indazol-1-yl)-acetic acid (0.146 g) which was taken into the next step without further purification.

Provenance & Evidence