HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 14041199, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-Tert-butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate | HCID 14772683 | — |
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 14041199 | HCID 14041199 | — |
Reaction Steps
A mixture of 4-azido-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester in CF3COOH/CH2Cl2 is stirred overnight at room temperature. To a solution of the obtained product in DCM is added a corresponding unsubstituted or halogen-substituted benzaldehyde, acetic acid and NaBH(OAc)3. After stirred overnight, the reaction mixture is purified to afford the corresponding product 4-azido-1-benzyl-pyrrolidine-2-carboxylic acid methyl ester (9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-f3093227f1c54790a3ff1a2f3b60669c |
| Source note | uspto-grants-2009_05 |