HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 1-Benzyl-4-[tert-butoxycarbonyl-(benzyl)-amino]-pyrrolidine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 1-Benzyl-4-[tert-butoxycarbonyl-(benzyl)-amino]-pyrrolidine-2-carboxylic acid methyl ester | HCID 67548815 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Benzyl-4-[tert-butoxycarbonyl-(benzyl)-amino]-pyrrolidine-2-carboxylic acid | HCID 67549368 | — |
Reaction Steps
To a solution of 1-benzyl-4-[tert-butoxycarbonyl-(benzyl)-amino]-pyrrolidine-2-carboxylic acid methyl ester (11) in CH3OH is added LiOH, and the solution is stirred overnight at rt. After removal of solvent, the residue is dissolved in water, acidified until PH=5, and then extracted with EA, and concentrated to afford the product 1-benzyl-4-[tert-butoxycarbonyl-(benzyl)-amino]-pyrrolidine-2-carboxylic acid (12).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-70379a9e633f41f2841f88c31c21350c |
| Source note | uspto-grants-2009_05 |