HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | Benzyl-4-oxo-pyrrolidine-2-carboxylic acid methyl ester | HCID 67548133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester | HCID 67548836 | — |
Reaction Steps
1-Benzyl-4-oxo-pyrrolidine-2-carboxylic acid methyl ester and a corresponding benzylamine are dissolved in DCM, acetic acid and NaBH(OAc)3 is then added. After stirred for about 3 hours the reaction mixture is diluted with DCM, washed, dried and concentrated. The residue is purified to afford 1-benzyl-4-(benzylamino)-pyrrolidine-2-carboxylic acid methyl ester (26).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07528136B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-70c3a89c2bae48c99a026ba484baebd5 |
| Source note | uspto-grants-2009_05 |